Abstract Search

ea0029p1203 | Obesity | ICEECE2012

Loss of hypothalamic-pituitary-adrenal axis improves obese phenotype and restores hypothalamic agouti-related protein mRNA in leptin-deficient ob/ob mice

Nishiyama M. , Nakayama S. , Okazaki M. , Tsugita M. , Taguchi T. , Makino S. , Okada Y. , Tsuda M. , Iwasaki Y. , Terada Y.

Purpose: Glucocorticoid excess causes obesity and hyperphagia (e.g. Cushing syndrome), but the molecular mechanism of glucocorticoid-induced hyperphagia is not fully understood. To clarify this point, we investigated here the phenotype of leptin and Corticotropin-releasing hormone (CRH) double knockout mice (DKO).Methods: Leptin-deficient ob/ob mice were bred with CRH-deficient mice for generation of DKO mice. We examined body weight, food consumption an...

0 shares

ea0029p213 | Calcium & Vitamin D metabolism | ICEECE2012

Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

Terada Y. , Shimamura Y. , Hamada K. , Inoue K. , Ogata K. , Ishihara M. , Kagawa T. , Inoue M. , Fujimoto S. , Ikebe M. , Yuasa K. , Yamanaka S. , Sugiura T. , Nishiyama M.

Background: α-Klotho was first identified as an aging gene and was later shown to be a regulator of phosphate metabolism. Fibroblast growth factor 23 (FGF23) is the key regulator of phosphate metabolism. Serum levels of soluble α-Klotho in chronic kidney disease (CKD) patients have not previously been determined, especially in relation with FGF23 and creatinine levels. This study was designed to investigate whether serum soluble α-Klotho levels are modulated by ...

0 shares

Endocrine Abstracts

Loss of hypothalamic-pituitary-adrenal axis improves obese phenotype and restores hypothalamic agouti-related protein mRNA in leptin-deficient ob/ob mice

Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

BiosciAbstracts